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Rat CASP3 (Cysteinyl aspartate specific proteinases 3) ELISA Kit
Rat CASP3 (Cysteinyl aspartate specific proteinases 3) ELISA Kit
The Rat (CASP3) Cysteinyl aspartate specific proteinases 3 ELISA Kit measures Cysteinyl aspartate specific proteinases 3 in Rat samples.
Catalog No:
E0280Ra
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Rat
Sensitivity
0.022 ng/mL
Detection Range
0.05-10 ng/mL
Sample Type
Serum, Plasma, Urine, Ascites, Cerebrospinal fluid, Tissue
Incubation(s)
1.5 hour(s)
Research Areas
Cell Biology, Cancer, Neuroscience
Background
Caspase-3 is a cytoplasmic cysteine protease involved in the activation cascade of caspases responsible for execution of apoptosis. At the onset of apoptosis caspase-3 cleaves and activates caspase-6, -7 and -9. It also cleaves poly (ADP-ribose) polymerase (PARP). Caspase-3 cleaves and activates sterol regulatory element binding proteins (SREBPs). Caspase-3 is involved in the cleavage of huntingtin. Caspase-3 is expressed in an inactive pro-form (pro caspase-3). In apoptosis, the pro caspase-3 is activated by proteolytic cleavages at Asp28-Ser29 and Asp175-Ser176 bonds catalyzed by granzyme B, caspase-6, caspase-8, caspase-9 and caspase-10, generating two subunits p17 and p12 that are assembled into heterotetrameric active enzyme. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. The pro-form and the active form are useful biomarkers of apoptosis. Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Cysteinyl aspartate specific proteinases 3
Regulatory Status
For Research Use Only
