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Rat HTR2B (5-Hydroxytryptamine Receptor 2B) ELISA Kit
Rat HTR2B (5-Hydroxytryptamine Receptor 2B) ELISA Kit
The Rat (HTR2B) 5-Hydroxytryptamine Receptor 2B ELISA Kit measures 5-Hydroxytryptamine Receptor 2B in Rat samples. The plate has been pre-coated with Rat HTR2B antibody. HTR2B present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Rat HTR2B Antibody is added and binds to HTR2B in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated HTR2B antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Rat HTR2B. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E1836Ra
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
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per
2.5 weeks
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Product Details
Species Reactivity
Rat
Sensitivity
5.13 ng/L
Detection Range
10-2000 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Neuroscience
Background
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed: 1505525, PubMed: 1331748). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed: 22525520). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed: 1505525, PubMed: 1331748). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (By similarity). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity). May play a role in the perception of pain (PubMed: 22525520). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
5-Hydroxytryptamine Receptor 2B
Regulatory Status
For Research Use Only
