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Rat NPAS4 (Neuronal Pas Domain-containing Protein 4) ELISA Kit
Rat NPAS4 (Neuronal Pas Domain-containing Protein 4) ELISA Kit
The Rat (NPAS4) Neuronal Pas Domain-containing Protein 4 ELISA Kit measures Neuronal PAS domain-containing protein 4 in Rat samples. The plate has been pre-coated with Rat Npas4 antibody. Npas4 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Rat Npas4 Antibody is added and binds to Npas4 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated Npas4 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Rat Npas4. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E2479Ra
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
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2.5 weeks
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Product Details
Species Reactivity
Rat
Sensitivity
5.06 ng/L
Detection Range
10-2000 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Neuroscience
Background
Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus (By similarity).
Plays a key role in the structural and functional plasticity of neurons (By similarity).
Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity).
In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity).
In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity).
The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (PubMed:21887312).
Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity).
Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (By similarity).
Can activate the CME (CNS midline enhancer) element (By similarity). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Neuronal PAS domain-containing protein 4
Regulatory Status
For Research Use Only
