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Rat RUNX1 (Runt-related Transcription Factor 1) ELISA Kit
Rat RUNX1 (Runt-related Transcription Factor 1) ELISA Kit
The Rat (RUNX1) Runt-related Transcription Factor 1 ELISA Kit measures Runt-related transcription factor 1 in Rat samples. The plate has been pre-coated with Rat RUNX1 antibody. RUNX1 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Rat RUNX1 Antibody is added and binds to RUNX1 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated RUNX1 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Rat RUNX1. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E2243Ra
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
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per
2.5 weeks
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Product Details
Species Reactivity
Rat
Sensitivity
6.23 ng/L
Detection Range
15-3000 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Background
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (By similarity).
Positively regulates the expression of RORC in T-helper 17 cells (By similarity). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Runt-related transcription factor 1
Regulatory Status
For Research Use Only
